摘要
目的:检测舌鳞癌组织中凋亡抑制蛋白Survivin的表达,探讨Survivin在舌鳞癌中的临床意义。方法:应用免疫组织化学方法检测10例正常舌黏膜、13例高分化舌鳞癌、20例中分化舌鳞癌和12例低分化舌鳞癌标本中Survivin的表达情况。采用SPSS13统计软件包进行非参数Kruskal-wallis检验及Mann-Whitney U检验。结果:舌鳞癌标本中Survivin的阳性表达率为68.9%,显著高于正常对照组(P<0.01),Survivin蛋白表达与舌鳞癌组织学分级, TNM分期相关(P<0.05),与淋巴结转移密切相关(P<0.01)。结论:Survivin在不同分化阶段的舌鳞癌中明显增加,与舌鳞癌发生、临床进展及预后密切相关,有望成为舌鳞癌治疗的新靶点。
PURPOSE: To investigate the expression of Survivin,one of inhibitors of apoptosis proteins(IAPs) in tongue squamous cell earcinoma(TSCC), and discuss its clinical significance. METHODS: Immunohistochemical staining was employed to detect the expression of Surwivin in 10 normal lingual mucosal membranes, 13 highly differentiated SCCs,20 medium-differentiated SCCs and 12 low-differentiated SCCs. Data was analyzed with SPSS13 software package for nonparametrie Kruskal-Wallis test and Mann-Whitney U test. RESULTS: The positive staining rate of Survivin in TSCC was 68.9%, and significantly higher than that in normal control group (P〈0.01). Overexpression of Survivin was related to the pathological grade , TNM stage (P〈0.05) and closely to lymph node metastasis of TSCC (P〈0.01). CONCLUSIONS: The positive staining of Survivin increased in different grades of TSCC, and Survivin is relative to carcinogenesis. progression and prognosis of TSCC. It may be a new clinical therapeutic target for TSCC.Supported by Research Fund of Science and Technology, Project of Liaoning Province (Grant NO.2005225007-1).
出处
《上海口腔医学》
CAS
CSCD
2007年第2期157-160,共4页
Shanghai Journal of Stomatology
基金
辽宁省科学技术计划资助课题(2005225007-1)
关键词
凋亡抑制蛋白
SURVIVIN
鳞癌
舌
Inhibitor of apoptosis proteins
Survivin
Squamous cell carcinoma
Tongue