Survivin在舌鳞癌中的表达及意义

Expression of Survivin and its significance in tongue squamous cell carcinoma

目的:检测舌鳞癌组织中凋亡抑制蛋白Survivin的表达,探讨Survivin在舌鳞癌中的临床意义。方法:应用免疫组织化学方法检测10例正常舌黏膜、13例高分化舌鳞癌、20例中分化舌鳞癌和12例低分化舌鳞癌标本中Survivin的表达情况。采用SPSS13统计软件包进行非参数Kruskal-wallis检验及Mann-Whitney U检验。结果:舌鳞癌标本中Survivin的阳性表达率为68.9％,显著高于正常对照组(P<0．01),Survivin蛋白表达与舌鳞癌组织学分级, TNM分期相关(P<0．05),与淋巴结转移密切相关(P<0．01)。结论:Survivin在不同分化阶段的舌鳞癌中明显增加,与舌鳞癌发生、临床进展及预后密切相关,有望成为舌鳞癌治疗的新靶点。

PURPOSE： To investigate the expression of Survivin,one of inhibitors of apoptosis proteins（IAPs） in tongue squamous cell earcinoma（TSCC）, and discuss its clinical significance. METHODS： Immunohistochemical staining was employed to detect the expression of Surwivin in 10 normal lingual mucosal membranes, 13 highly differentiated SCCs,20 medium-differentiated SCCs and 12 low-differentiated SCCs. Data was analyzed with SPSS13 software package for nonparametrie Kruskal-Wallis test and Mann-Whitney U test. RESULTS： The positive staining rate of Survivin in TSCC was 68.9%, and significantly higher than that in normal control group （P〈0.01）. Overexpression of Survivin was related to the pathological grade , TNM stage （P〈0.05） and closely to lymph node metastasis of TSCC （P〈0.01）. CONCLUSIONS： The positive staining of Survivin increased in different grades of TSCC, and Survivin is relative to carcinogenesis. progression and prognosis of TSCC. It may be a new clinical therapeutic target for TSCC.Supported by Research Fund of Science and Technology, Project of Liaoning Province （Grant NO.2005225007-1）.