臭氧治疗细菌性阴道病的疗效评价

Evaluation on the therapeutic effects of ozone for the treatment of bacterial vaginosis

目的评价臭氧治疗细菌性阴道病的有效性和安全性。方法采用随机对照、开放设计的方法,收集在中山大学附属第三医院就诊的细菌性阴道病患者72例,其中试验组36例接受臭氧治疗,对照组36例接受甲硝唑栓治疗,于治疗结束后第3天观察临床症状及体征变化,并运用BV蓝快速诊断试剂检测阴道分泌物。结果治疗结束后第3天,试验组和对照组的治愈率分别为61.1%和63.4%,有效率分别为80.6%和88.9%,症状平均缓解时间分别为3.72天和3.53天,阴道分泌物BV蓝检测阴转率均为100%。两组之间比较差异均无显著性(P>0.05)。72例中无不良事件与严重不良事件发生。结论臭氧治疗细菌性阴道病安全、有效。

Objective To evaluate the efficacy and safety of ozone used in the treatment of bacterial vaginosis. Methods A randomized and controlled trial was conducted in the Third Affiliated Hospital of Sun Yat-sen University. 72 cases of bacterial vaginosis were involved and randomly divided into trial group and control group. 36 cases in the trial group were given ozone therapy and 36 cases in control group were given metronidazole suppositories. Changes in clinical symptoms, signs and the result of BV blue examination were compared between the trial group and control group 3 days after the end of treatment. Results 3 days after the end of treatment, the cure rate was 61.1% /or trial group and 63. 4% for control group, the efficacy rate was 80. 6% in trial group and 88. 9% in control group. There was no significant difference between the two groups in clinical efficacy （P〈0.05）. The average period of symptoms relief was 3. 72 days in trial group and 3. 53 days in control group, respectively. There were no significant differences between these two groups in the speed of relaxing clinical symptoms （P〈0. 05）. The eradication rate of pathogen was 100% in both trial group and control group with no significant differences （P〈0. 05）. There were no adverse events or severe adverse events in all these 72 cases. Conclusion Ozone is effective and safe in the treatment of bacterial vaginosis.