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基因重组生长激素治疗青春期前特发性矮小疗效观察 被引量：8

Effect of recombinant human growth hormone therapy in prepuberty children with idiopathic short stature
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摘要 目的探讨基因重组人生长激素(rhGH)对青春期前特发性矮小(ISS)的疗效。方法观察27例青春期前特发性矮小患儿,平均年龄(8.9±2.0)岁,身高(118.0±10.6)cm。治疗组13例,男10例,女3例,均接受基因重组人生长激素治疗,剂量(0.12±0.01)IU/kg,睡前皮下注射,疗程6个月至1年;对照组14例,男6例,女8例。结果治疗组患儿生长速率(GV)由治疗前(4.28±0.86)cm/a提高到(9.38±1.77)cm/a,P<0.01;年龄身高标准差积分(HtSDSCA)由-2.28±0.48增至-1.72±0.62(P<0.01);骨龄身高标准差积分(HtS-DSBA)由-0.24±1.02增至0.27±0.99(P<0.05);与对照组比较,GV、HtSDS(CA)和HtSDS(BA)差异均有统计学意义(P均<0.05);两组△BA/△CA比较差异无统计学意义(P均>0.05)。结论GH治疗能改善ISS儿童的GV及HtSDS(CA)、HtSDS(BA),而骨龄(BA)加速不明显,疗效肯定。
作者 张宇 陆文丽 杨立础 李温慈 王伟 陈凤生 王德芬
机构地区 浙江省温州市第二人民医院儿科 上海交通大学医学院附属瑞金医院儿科
出处 《临床儿科杂志》 CAS CSCD 北大核心 2007年第5期393-395,共3页 Journal of Clinical Pediatrics
关键词 生长激素 特发性矮小 青春前期 growth hormone idiopathic short stature prepuberty
分类号 R725.8 [医药卫生—儿科]
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参考文献13

  • 1国家体育总局群体司编．2000年国民体质临测报告[M]．北京体育大学出版社，2002：105，124．
  • 2Wyatt D. Lessons from the national cooperative growth study[J]. Eur J Endocrinol, JT-European, 2004, 151 (Suppl 1 ) :S55-S59.
  • 3Salerno M,Balestrieri B,Matrecano E,et al. Abnormal GH receptor signaling in children with idiopathic short stature [J]. J Clin Endocrinol Metab, 2001, 86(8): 3882-3888.
  • 4Binder G,Schwarze CP,Ranke MB. Identification of short stature caused by SHOX defects and therapeutic effect of recombinant human growth hormone [J]. J Clin Endocrinol Metab, 2000,85 ( 1 ) : 245-249.
  • 5Rao E ,Weiss B,Fukami M ,et al. Pseudoautosomal deletions encompassing a novel homeobox gene cause growth failure in idiopathic short stature and Turner syndrome [J]. Nat Genet, 1997,16( 1 ) :54-63.
  • 6陈晓丽.特发性矮小的相关基因研究进展[J].国外医学（妇幼保健分册）,2002,13(5):227-231. 被引量：10
  • 7李燕虹,杜敏联,苏喆,马华梅,古玉芬.小剂量司坦唑醇对非生长激素缺乏症矮小儿童促生长疗效观察[J].临床儿科杂志,2004,22(8):518-519. 被引量：6
  • 8应艳琴,罗小平.生长激素在儿科临床的应用——现状与循证[J].临床儿科杂志,2005,23(8):499-503. 被引量：9
  • 9Hintz RL, Attic KM, Baptista J, et al. Effect of growth hormone treatment on adult height of children with idiopathic short stature [J]. Genenteeh Collaborative Group,N Engl J Med, 1999,340(7) :502-507.
  • 10Kawai M,Momoi T,Yorifuji T,et al. Unfavorable effects of growth hormone therapy on the final height of boys with short stature not caused by growth hormone deficiency [J]. J Pediatr, 1997,130(2) :205-209.

二级参考文献62

  • 1Hintz RL, Attic KM, Baptista J, et al. Effect of growth hormone treatment on adult height of children with idiopathic short stature[J]. N Engl J Med,1999;340(7):502--507.
  • 2Kawai M, Momoi T, Yorifuji T, et al. Unfavorable effects of growth hormone therapy on the final height of boys with short stature not caused by growth hormone deficiency[J ]. J Pediatr, 1997; 130 (2) :205--209.
  • 3Goddard AD, Covello R, Luoh SM, et al. Mutations of the growth hormone receptor in children with idiopathic short stature [J ]. N Engl J Med, 1995;333(17) : 1093-1098.
  • 4Loche S, Cambiaso P, Setau S, et al. Final height after growth hormone therapy in non-growth-hormone-deficient children with short stature[ J ]. J Pediatr, 1994:125 : 196-- 200.
  • 5Crowne EC,Wallace WHB,Moore C,et al. Effect of low dose oxandrolone and testosterone treatment on the pituitary-testicular and GH axes in boys with constitutional delay of growth and puberty. Clin Endocrinol, 1997,46: 209-216.
  • 6Le Roith D,Bondy C ,Yakar S,et al.The somatomedin hypothesis:2001.Endocrin Rev, 2001,22:53-74.
  • 7Martina W,Stacy DL,Kevin M,et al. Effects of estrogen on growth plate senescence and epiphyseal fusion.Proc Natl Acad Sci, 2001,98: 6871-6876.
  • 8Peralta JM,Arnold AM,Currie WB,et al. Effects of testosterone on skeletal growth in lambs as assessed by labeling index of chondrocytes in the metacarpal bone growth plate.J Anim Sci,1994,72: 2629-2634.
  • 9Rikken MB, Massa GG, Wit JM.Final height in a large cohort of Dutch patients with growth hormone deficiency treated with growth hormone.Horm Res, 1997, 48: 62-71.
  • 10Tanaka T, Cohen P, Clayton PE, et al.Diagnosis and management of growth hormone deficiency in childhood and adolescence.Part 2: Growth hormone treatment in growth hormone deficient children.Growth Horm IGF Res, 2002, 12: 323-341.

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临床儿科杂志
2007年 第5期

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