实验性自身免疫性脑脊髓炎巨噬细胞活性MR成像的研究进展

Progress of macrophage activity on magnetic resonance imaging in experimental autoimmune encephalomyelitis

MR成像是监测多发性硬化(MS)病情及其演变、评价疗效的重要手段,实验性自身免疫性脑脊髓炎(EAE)是公认的研究人类多发性硬化的动物模型。常规MR扫描仅能分析MS和EAE炎症反应的继发性改变。巨噬细胞是MS和EAE炎症反应中重要的效应细胞,超微超顺磁性氧化铁(USPIO)粒子能被巨噬细胞摄取,MR成像能显示MS和EAE病灶内吞噬了USPIO的巨噬细胞,分析其炎症反应自身的信息,是动态观察巨噬细胞浸润过程、进一步探索MS免疫病理机制的有效手段。本文综述超微超顺磁性对比剂的特性及其MR成像在EAE和MS病理机制方面的研究进展,评价其发展前景。

MRI is an important tool for monitoring the development of lesions and assessing the efficacy of treatment in multiple sclerosis （MS） in vivo. Experimental autoimmune encephalomyelitis （EAE） is a received animal model for studying MS in human. Conventional MRI can only provide information on the consequences of inflammation. Macrophages play a key role in the inflammatory and tissue degeneration of MS and EAE. Ultra-small supperparamagnetic iron oxide （USPIO） MR imaging can reveal the presence of maerophages in MS and EAE lesions, analyze the information of inflammatory activity itself. It offers a method for monitoring the infiltrations of macrophage and investigating of the etiology and pathogenesis of MS. This article summarizes the USPIO characteristics and USPIO MR imaging in studying the pathogenesis of EAE and MS, demonstrates its clinical benefit.