摘要
With its incidence (10–11 per 100, 000 people) almost equaling its prevalence, pancreatic cancer is one of the most aggressive human tumors. Understanding the exceptionally aggressive behavior has been the objective of clinical and basic research elucidating in detail the molecular changes that lead to the development and the progression of this disease. The molecular alterations
With its incidence （10-11 per 100, 000 people） almost equaling its prevalence, pancreatic cancer is one of the most aggressive human tumors. Understanding the exceptionally aggressive behavior has been the objective of clinical and basic research elucidating in detail the molecular changes that lead to the development and the progression of this disease. The molecular alterations observed range from gross chromosomal abnormalities to gene mutations and epigenetic changes, which contribute together to the aggressive growth of pancreatic cancer with retroperitoneal and perineural infiltration, angioinvasion, and early metastases. Clinically, pancreatic cancer is characterized by high rates of local relapse after resection,
