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DNA甲基化标志在胃肠肿瘤中的临床应用

Clinical application of marker based on DNA methylation in gastrointestinal tumor
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摘要 DNA甲基化是高等真核生物中经常发生的现象,这种表观遗传学改变常发生在基因的启动子区域,并且不改变DNA序列和遗传密码,具有可逆性,在基因转录调控中发挥重要作用。已近知道抑癌基因和一些与正常细胞功能相关基因的转录失活与DNA甲基化有关,在胃肠肿瘤的发生,发展中起重要作用。随着对DNA甲基化的分子机制的进一步认识,以甲基化为基础的标志在临床的应用,尤其是肿瘤的防治,展现了广阔的前景。目前,这一标志及其相关技术在临床的应用涉及到诊断及治疗等方面,诸如患病风险评估、早期诊断、预后判定、复发监测、治疗反应监测和治疗计划的制定以及可作为治疗靶点等。就DNA甲基化肿瘤标志在胃肠肿瘤中的临床应用研究进展作一综述。 DNA methylation is a kind of ordinary pheonemena in eukaryote. This epigenetic modification is reversible, and it occurs often in the promoter region of genes without change of DNA sequence and genetic code, and plays an important role in the regulation of genetic transcription. As we have knowen that. DNA methylation is associated with transcriptional silencing of tumor suppressors or other genes important for normal cellular function and plays an important role in the develnpment of gastro intestinal tumor. With the increased knowledge of molecular mechanism of DNA methylation, the markers based on DNA methylation have got extensive research on the diagnosis and treatment of gastrointestinal tumor, such as risk appraisal, early diagnosis, prognosis assessment, recurrence monitoring, thera peutic reaction monitoring, target of therapy, etc. Here we： re view the advancement of clinical application of DNA methylation tumor marker for gastrointestinal tumor.
作者 齐翀 刘炳亚
机构地区 上海交通大学医学院附属瑞金医院外科上海消化外科研究所
出处 《中华肿瘤防治杂志》 CAS 2007年第8期628-630,共3页 Chinese Journal of Cancer Prevention and Treatment
关键词 DNA甲基化 肿瘤标记 生物学 胃肠肿瘤 综述文献 DNA methylationt tumor markers, biology gastrointestinal neoplasms review literature
分类号 R735 [医药卫生—肿瘤]
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中华肿瘤防治杂志
2007年 第8期

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