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子宫腺肌病患者在位与异位内膜热休克蛋白27的表达及意义

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摘要 目的研究子宫腺肌病(AM)患者在位及异位内膜中热休克蛋白27(HSP27)的表达水平及其在AM发生发展中的意义。方法采用免疫组化SABC法检测AM患者在位及异位内膜各40例和正常子宫内膜40例中HSP27表达情况。结果AM患者在位内膜组HSP27的表达低于异位内膜组(P<0.05),两组均显著高于正常子宫内膜组(P均<0.01)。AM患者在位及异位内膜中,增生期与分泌期相比HSP27表达差异无显著性(P>0.05),正常子宫内膜增生期与分泌期相比HSP27表达差异有显著性(P<0.05)。结论AM患者在位及异位内膜HSP27的表达高于正常子宫内膜,并且失去在正常子宫内膜中的周期性变化。HSP27表达水平升高在AM的发生发展中有重要意义。子宫内膜中HSP27表达水平的检测,对AM的诊断有一定参考价值。
出处 《右江民族医学院学报》 2007年第3期416-417,共2页 Journal of Youjiang Medical University for Nationalities
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