顺铂 鸦胆子油乳 干扰素 地塞米松联合金葡液腹腔灌注疗效观察

Effect of United Abdominal Cavity Perfusion with Cisplatin、Fructus bruceae emulsion、Interferon-α、Staphylococcin Aureus and Dexamethasone in patients with malignant peritoneal effusion or abdominal cavity metastasis

目的观察顺铂、鸦胆子油乳、干扰素、地塞米松联合金葡液腹腔灌注治疗恶性腹腔积液、腹腔转移癌的疗效。方法81例患者常规腹腔穿刺,有腹腔积液者抽尽腹腔积液,腹腔内注入顺铂60～100mg、鸦胆子油乳20ml、干扰素300万U、金葡液2500U和地塞米松10mg;无腹腔积液者上述药物至少溶入1500ml生理盐水中腹腔灌注。结果Karnofsky评分结果,显效17例,有效55例,总有效率88.9%;腹腔积液组:显效11例,有效19例,有效率90.9%。结论顺铂、鸦胆子油乳、干扰素、地塞米松联合金葡液腹腔免疫化疗治疗恶性腹腔积液疗效好、耐受性好、副作用小,经过治疗患者生活质量明显提高。

Objective To evaluate the efficacy of united abdominal cavity perfusion with Cisplatin.Fructus bruceae emulsion.Interferon- α.Staphylococcin Aureus and Dexamethasone in patients with malignant peritoneal effusion or abdominal cavity tumor. Methods Eight-one cases were treated with peritoneal infusion of Cisplatin 60-100 mg.Fructus bruceae emulsion 20 ml.Interferon- α 300 WU.Staphylococcin Aureus 2 500 U and Dexamethasone 10 mg. Results Karnofsky score,obviously reponse 17cases, part response 55 cases, total effective rate was 88.9%. peritoneal effusion group：obviously response 11 cases, part response 19 cases,total effective rate was 90.9%. Conclusions This treatment had good effect, and it was tolerable, reducing side effects, improving life quality with united intraperitoneal chemotherapy and immunotherapy in patients with malignant peritoneal effusion or abdominal cavity metastasis.