噪声应激对大鼠脑内c-fos表达的影响

Effects of noise stress on expression of Fos protein in rat brain.

采用噪声应激的大鼠模型,以免疫组化法检测在慢性应激过程中大鼠脑内有关神经核的Fos蛋白表达.结果表明:下丘脑的室旁核(PVN)、视上核(SON)与脑桥蓝斑(LC)的Fos蛋白表达高峰出现在噪声应激的第5 d,而边缘前脑的海马(HC)和杏仁核则出现在第10 d,以后Fos蛋白表达逐渐减少,而且100 dB组比80 dB组的Fos蛋白表达水平更高.提示噪声应激的Fos蛋白表达不仅与刺激类型与强度有关,且有多重脑机制的参与.

In the model of rats with noise stress, the expression of Fos protein in brain was examined by immunohistochemical method during the chronic stress process. The results showed that the peak expression of Fos in paraventricular nucleus （PVN）, supraoptic nucleus （SON） and locus coeruleus （LC） of hypothalamus appeared at the fifth day of the noise stress, while the peak expression in hippocampus （HC） and corpus amygdaloideum （CA） of limbic forebrain appeared at the tenth day. Since then the expression level was reduced gradually. In addition, the level of the Fos expression in 100 dB was higher than that in 80 dB. It was indicated that the Fos expression in noise stress was not only associated with the type and intensity of stress, but also with the multiple mechanisms in brain.