肝脏三种酶在肝移植术后的变化及意义

Significance of monitoring actinitis of three serum enzymes after hepatic transplantation

目的探讨肝移植术后监测醛缩酶、亮氨酸转肽酶和谷氨酸脱氢酶的意义。方法采用全自动生化分析仪测定血液醛缩酶,亮氨酸转肽酶和谷氨酸脱氢酶活性变化。结果醛缩酶和谷氨酸脱氢酶在术后5 d升高明显,亮氨酸转肽酶降低显著,随着术后时间延长,醛缩酶和谷氨酸脱氢酶逐渐降低,而亮氨酸转肽酶则逐渐升高。结论肝移植术后血清醛缩酶、亮氨酸转肽酶和谷氨酸脱氢酶可作为新植入肝脏肝细胞损伤的有效指标,为临床治疗提供帮助。

Objective To investigate the clinical significance of monitoring senma aldolase （AID）, leucine aminopeotidase （LAP） and glutamic dehydrogenase （GLDH） activities after hepatic transplantation. Methods The changes of the three enzymes in 134 liver- transplanted patients before and after operation were observed.Results The activities of senma AID and GLDH increased while that of senma LAP decreased significantly 5 days after transplantation. With time, vice versa. Conclusion Serum AID, LAP and GLDH levels are effective markers of heoatocellular damage after liver - transplantation and conducive to clinical therapy.