35例慢性阻塞性肺疾病肺气虚证患者血液纤溶活性变化的观察

Investigation of activity of fibrinolysis in patients blood with chronic obstructive pulmonary disease of qi deficiency

目的观察慢性阻塞性肺疾病气虚证患者血液纤溶活性的改变。方法选取中医辨证为肺气虚证的慢性阻塞性肺疾病患者35例,检测其纤溶原激活物(t-PA)、纤溶原抑制物(PAI-1)的活性改变,进行治疗前后对比,并与30例健康人正常对照组比较。结果慢性阻塞性肺疾病肺气虚证患者t-PA活性减低,PAI-1活性升高,治疗前后比较及与健康人正常对照组比较,差异均有统计学意义(P<0.05)。结论慢性阻塞性肺疾病肺气虚证患者存在纤溶活性的改变,血液处于高凝状态,与中医“气不行血”理论相一致。

Objective To observe the change of activity of fibrinolysis in patients blood with chronic obstructive pulmonary disease of qi defieieney. Methods 35 patients with ehronie obstruetive pulmonary disease of qi Defieieney were eheose. The ehanges of activity of tissue - type plasminogen activator （t - PA） and plasminogen activator inhibitor （PAI - 1 ） were measured before and after treatment. Results Aetivity of t - PA in patients with ehronie obstruetive pulmonary disease of qi defieieney were deereased, and activity of PAI- 1 was inereased. Them was a significant differenee between before and after treatment （ P 〈 0.05）. Conclusion Them was a ehange of activity of fibrinolysis in patients blood with ehronie obstruetive pulmonary disease of qi defieieney. The blood in patients was hypereoagulabale state in aceording with theory of TCM.