代谢综合征患者冠脉血流储备变化及其影响因素的研究

The study on changes and influential factors of the coronary flow reserve in metabolic syndrome

目的探讨代谢综合征(MS)患者冠脉血流储备(CFR)的变化及其相关影响因素。方法选择37例患者2、0例正常人分别经食道超声心动图法(TEE)测定左冠状动脉前降支近端(LAD)血流储备,测定体重、身高、腰围、血压、血脂、血糖、尿酸。结果MS患者CFR为1.95±0.31,正常人CFR为3.75±0.72,MS的CFR较正常人明显降低(P<0.001);多元线性回归显示:体重、腰围、血压、血脂、血糖、尿酸是与CFR降低相关的危险因素(P<0.05-0.001);Logistic回归显示:腰围、收缩压是独立危险因素。结论MS患者存在CFR降低,且可能是由多种危险因素共同作用的结果。

Objective To investigate the coronary flow reserve （CFR） and influential factors in metabolic syndrome （MS）. Methods The left anterior descending flow reserve of coronary artery was examined in 37 patients and 22 controls by using transesophageal echocsrdio graphy. Weight, stature, waist circumference, blood pressure, lipid lipemia, fasting blood glucose and uricemia were also measured. Results CFR in MS and control group were 1.95 ± 0.31 and 3.75 ±0. 72, respectively. The CFR in MS group was lower than that in control group （ P 〈 0. 001）. Waist circumference and blood pressure were dependent factors by using logistic regression analysis. The weight , waist circumference, blood pressure, lipid lipemia, fasting blood glucose and uricemia were found to be dangerous factors associated with CFR （ P 〈 0.05 - 0.001） by using multiple regression analysis. Conclusion CFR can be declined in MS, which can result in several dangerous factors（ P 〈 0.05）.