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羟基喜树碱联合LFP方案治疗晚期胃肠道肿瘤的临床观察

HCPT Combined with LFP in theTreatment of Advanced Gastrointestinal Cancers
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摘要 目的观察HCPT联合LFP方案治疗晚期胃肠道肿瘤的近期疗效。方法HCPT6mg/m2,第1~5天;DDP60~80mg/m2(总量),第1~5天;CF200mg/d,第1~5天;5-Fu0.6g/m2,第1~5天;每21天为1个周期,化疗3个周期的评定疗效。结果全组总有效率(CR+PR)为50.00%(26/52),化疗受益率(CR+PR+SD)为84.60%(42/52)。主要不良反应为骨髓抑制和消化道症状,大多为Ⅰ、Ⅱ度,其他反应轻微。结论HCPT联合LFP方案治疗晚期胃肠道肿瘤,疗效较好,且稳定率较高,不良反应轻,价格低廉,值得临床推广应用。 Objective To study the efficacy and toxicities of the regimen of hydroxycamptothecine (HCPT) combined with fleucovorin (CF) ,5-fluorouracil (5-FU) and cisplatin (DDP) ( LFP regimen) in the treatment of gastrointestinal cancers. Methods Patients with gastrointestinal cancers received HCPT combined with LFP regimen ( HCPT 6 mg/m^2, from day one to day 5, DDP 60 - 80 mg/m^2, from day 1 to day 5, CF200 mg/d, from day 1 to day 5, and 5-Fu 0.6 g/m^2, from day 1 to day 5. The chemotherapy was repeated every 3-week,for a total of 3 cycles. Results The overall response rate was 50.00% (26/52). The chemicotherapy benefit rate( CR + PR + SD) was 84.6% (42/52) in whole groups. The main side effects were myelosuppression, nausea, vomiting and diarrhea, most of which were grade Ⅰ to grade Ⅱ. Conclusion HCPT Combined with LFP is effective in the treatment of advanced gastrointestinal cancers with acceptable side-effects. Further clinical use is warrented.
出处 《实用癌症杂志》 2007年第3期274-275,278,共3页 The Practical Journal of Cancer
关键词 胃肠道肿瘤 羟基喜树碱 Gastrointestinal cancers Hydroxycamptothecine (HCPT)
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