双黄败毒颗粒的提取工艺研究

Study on Extraction Technology for Shuanghuangbaidu Granules

采用L9(3)4正交试验设计,以总固物收率和有效成分小檗碱含量作为考察指标,探讨双黄败毒颗粒提取工艺中的几个影响因素。试验结果与方差分析表明,提取次数影响最为明显,其次是加水量,而提取时间影响不大。选用提取3次、加水10倍量、每次提取1.5 h为最佳提取工艺条件。

Some influential factors were investigated by L^9 （3）4 orthogonal test in the Shuanghuangbaidu granules extracring process with water. Percentage of dry extract and berberine content as quality index were determined. The results of the experiment and variance analysis indicated that among the 3 factors, the extracting rimes has a great effect on the result, next was the water amount ,the extracting time was of little importance. 3 times of extracting,10 fold water of drug mass and 1.5 h of the extracting time were the optimum extracting conditions.