护肝颗粒对小鼠急性肝损伤的保护作用

Protective Effect of Hugan Granules on Acute Liver Injury Model Mice

目的:研究护肝颗粒对模型小鼠急性肝损伤的保护作用。方法:以0.12%氯仿-花生油溶液经腹腔注射,制备小鼠肝损伤模型,显微镜下观察肝组织病理学变化;测定丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、超氧化物歧化酶(SOD)活性及丙二醛(MDA)含量;计算肝脏指数。结果:高、中、低剂量护肝颗粒均能显著降低急性肝损伤模型小鼠血清中ALT、AST活性,提高其SOD活性,降低其MDA含量及肝脏指数。结论:护肝颗粒对急性肝损伤有一定的保护作用。

OBJECTIVE： To observe the protective effect of Hugan granules on the acute liver injury model mice. METHODS： Acute liver injury model was induced by intraperitoneal injection of 0.12% chloroform-peanut oil solution. The histopathological changes of the liver tissues were observed under microscope. The activities of ALT, AST and SOD and the content of MDA in the liver tissues were determined and the liver indexes were calculated. RESULTS： Hugan granules at high, medium and low doses could significantly lower serum ALT and AST activities, enhance the activity of SOD, and lower both MDA content and the liver index. CONCLUSION： Hugan granules have a certain protective effect on the acute liver injury.