乳痛消结颗粒中5种挥发油的提取及β-环糊精包合物的制备

Extraction of 5 Volatile Oils from Rutongxiaojie Granule and Preparation of β-cyclodextrin Inclusion Compound

目的:研究乳痛消结颗粒中5种药材所含挥发油的最优提取工艺及对所提挥发油的最优包合工艺。方法:采用正交试验法,以挥发油收率作为评价提取工艺的指标;以包合物收率、含油率和挥发油利用率的综合评分作为评价包合工艺的指标。结果:最优提取工艺为药材加10倍量水,浸泡1h,水蒸气蒸馏9h;最优包合工艺为挥发油∶β-环糊精=1∶8,包合温度30℃,包合时间20min。结论:该提取、包合工艺合理、可行。

OBJECTIVE： To optimize the extraction condition of volatile oil from five medicinal materials in Rutongxiaojie granules and to optimize the inclusion process of the extracted volatile oil. METHODS： The extraction condition was evaluated by orthogonal test with the recovery of volatile oil as indicator; and the inclusion condition was evaluated with the comprehensive scores of recovery ratio of inclusion compound, the content of volatile oil in inclusion compound and the utilization ratio of the volatile oil as criteria. RESULTS： The optimum extraction condition was established as follows： the medicinal materials were soaked in 10 times volume of water for 1hour and distilled for 9h by steam distillation. The optimum inclusion condition was as follows： the proportion of volatile oil to β-CD was 1 ： 8; the inclusion temperature was 30℃ and including time was 20min. CONCLUSION： Both the extraction condition and the inclusion condition were reasonable and feasible.