抑肽酶对四氯化碳所致急性肝损伤小鼠体内脂质过氧化的影响

Effects of aprotinin on Lipid Peroxidation of Mice Acute Liver Injury Induced by carbon tetrachloride

目的研究抑肽酶对四氯化碳所致急性肝损伤小鼠体内脂质过氧化的影响。方法以四氯化碳诱导小鼠急性肝损伤模型,测定各组肝损伤小鼠血清超氧化物岐化酶(SOD)、丙二醛(MDA)、还原型谷胱甘肽(GSH)水平,同步观察抑肽酶对急性肝损伤小鼠体内脂质过氧化反应及肝脏病理改变的影响。结果抑肽酶可明显升高小鼠血清SOD、GSH水平,降低MDA水平,肝脏病理学检查亦表明抑肽酶使肝细胞变性坏死程度减轻。结论提示抑肽酶通过抗脂质过氧化的作用发挥对急性肝损伤的保护作用。

Objective To investigate the effect of aprotinin on lipid peroxidation of mice acute liver injury induced by carbon tetrachloride. Methods The acute hepatic injury model of mice were induced by carbon tetrachloride （CC14）. Measuringthe changes of activity of serum superoxide dismutase （SOD）, malondialdehyde （MDA）, glutathice （GSH）, Observing the pathologic change of liver tissue. Results Aprotinin could increase the activities of serum SOD, GSH and decrease the lever of serum MAD. Aprotinin could improve the pathologic change of liver tissue of acute hepatic injury significantly. Conclusion Aprotinin has protective functions on mice with acute liver injury on lipid peroxidation.