炔雌醇＋去氧孕烯治疗青春期功能失调性子宫出血128例临床分析

Clinical analysis of ethinylestradio ＋desogestrel in treatment of pubertal dysfunctional uterine bleeding in adolescent patients

目的观察炔雌醇＋去氧孕烯（妈富隆）不同给药方法对青春期功能失调性子宫出血（功血）止血治疗的临床疗效，并与经典的雌激素（苯甲酸雌二醇）疗法相比较。方法青春期功血患者128例，其中A组44例，人院时血红蛋白（Hb）≤70g/L，人院后采用雌激素（苯甲酸雌二醇）为主的止血治疗。B、C组各42例，人院时Hb≥50g，L，均采用妈富隆为主的止血治疗，B组每日单次给药3片，血止后递减；C组每次1片，8h1次，血止后递减。结果使用妈富隆治疗的B、C组控制出血时间及完全止血时间与A组比较差异元统计学意义，但胃肠道不良反应小（P〈0．01）。A组住院39例，B、C组大部分患者不需住院，可以门诊治疗。B组和C组在治疗效果上差异元统计学意义，B组患者的顺应性更好。结论妈富隆用于青春期功血止血治疗效果好，给药简单、方便，副作用小，是一种值得推广应用的好方法。

Objective To observe the clinical efficacy of ethinylestradio＋desogestrel （mavelon） and estrogen in the treatment of acute bleeding episode of dysfunctional uterine bleeding in adolescent patients. Methods All 128 patients received hormonal therapy,44 patients（group A） with original Hb≤70 g/L were treated with estradiol benzoate, 84 patients（group B and group C） with original Hb≥50 g/L were treated with mavelon. Patients in group B were prescribed 3 tablets once and decreased the dose gradually after ceasing of hemorrhage. Patients in group C were prescribed 1 tablet every 8 hours and decreased the dose gradually after ceasing of hemorrhage. Results The time of controlling bleeding and the time of stopping bleeding in group B and group C were similar to those in group A. The side effect was slight （P〈 0.01 ）. There were 39 in-patients in group A, most of patients in group B and group C were out-patients. The clinical efficacy of group B was similar to group C. The compliance of patients in group B were better. Conclusions The clinical efficacy of mavelon on dysfunctional uterine bleeding in adolescent patients is signifieiant. It is simple method with slight side effect.