MMP-9在卵巢上皮性肿瘤中的表达及意义

The expression and significance of matrix metalloproteinases -9 in epithelial tumor of ovary

目的了解基质金属蛋白酶（MMP）-9在卵巢上皮性肿瘤中的表达情况，进而探讨MMP-9与卵巢癌局部侵袭、淋巴结转移情况以及肿瘤细胞分化程度的关系。方法收集卵巢恶性上皮性肿瘤组织50例（卵巢癌组），15例卵巢良性上皮性肿瘤和5例正常卵巢组织作为对照组。采用免疫组织化学方法进行定性分析。结果MMP-9的阳性表达率在卵巢癌组织中增高，达70．0％。MMP-9表达情况与肿瘤的临床分期、分化程度及淋巴结的转移情况有关。分别在进展晚期（89．3％）、低分化（81．8％）和有淋巴转移的组织中阳性率增高（93．8％）。结论卵巢癌中MMP-9的阳性表达率增高，MMP-9在卵巢癌局部侵袭和淋巴结转移过程中有促进作用，MMP-9与卵巢癌的分化程度有关。

Objective To detect the expression of matrix metalloproteinases （MMP）-9 in epithelial tumor of ovary, and explore the difference expression of MMP-9 between stages of TNM and the extent of differentiation. Methods Fifty cases of epithelial tumor of ovary, 15 cases of carcinoid and 5 cases of normal ovarian tissues were colleeted for the measurement of MMP-9 expression. Immunohistochemistry was used for qualitative analysis. Results The expression ratio of MMP-9 in epithelial tumor of ovary was 70.0% which was higher than that in normal ovarian and carcinoid tissues. The expression ratio of MMP-9 in low differentiation tissues was 81.8% which was higher than that in middle and high differentiation tissues. The expression ratio of MMP-9 in terminal epithelial tumor of ovary tissues was 89.3% which was higher than that in inchoate tissues. The expression ratio of MMP-9 in lymphatic metastasis epithelial tumor of ovary tissues was 93.8% which was higher than that in the other tissues. Conclusions The expression ratio of MMP-9 in epithelial tumor of ovary is higher than that in normal ovarian and carcinoid tissues. MMP-9 can improve the part invasion and lymph node metastasis in epithelial tumor of ovary. It is related with the extent of differenti- ation of epithelial tumor of ovary.