含羟基手臂双咪唑鎓氯盐的合成及其Pd络合物对Suzuki-Miyaura交叉偶联反应的催化活性

Synthesis of N-Hydroxyalkyl-substituted Bisimidazolium Chloride Salt and the Catalytic Activity of Its Pd-complex for Suzuki-Miyaura Cross-coupling Reaction

合成了一种新型含羟基手臂的双咪唑鎓氯盐(L.2HCl)。N2保护下L.2HCl与Pd(OAc)2原位制备N-杂环卡宾-Pd络合物。以DMF-H2O为溶剂,K2CO3为碱,该络合物催化溴代芳烃和芳基硼酸的Suzuki-Miyaura交叉偶联反应合成取代联苯,收率75%～99%。

A novel N-hydroxyalkyl-substituted bisimidazolium chloride salt （L · 2HC1） was synthesized. A bis（N-heterocyclic-carbene）complex of Pd was prepared in situ under N2 from L · 2HCl and Pd（OAc） 2. The complex catalyzed Suzuki-Miyaura cross-coupling reaction of arylbromides with arylboronic acids in DMF -H2O using K2CO3 as a base to obtain substituted-biphenyl in yields of 75% - 99%.