2-氯甲基-3-甲基-4-[(3-甲氧基)丙氧基]-吡啶盐酸盐的合成

Synthesis of 2-Chloromethyl-3-methyl-4-[(3-methoxy)propoxy]-pyridine Hydrochloride

以2,3-二甲基吡啶为原料,经6步反应合成了雷贝拉唑的关键中间体——2-氯甲基-3-甲基-4-[(3-甲氧基)丙氧基]-吡啶盐酸盐,总收率14.1%。

2-Chloromethyl-3-methyl-4-[ （3-methoxy） propoxy ]-pyridine hydrochloride （ a important intermediate for preparing Rabeprazole） was synthesized by a six-step reaction from 2,3-dimethylpyridine in overall yield of 14.1%.