超微孔膨体聚四氟乙烯人工二尖瓣体外脉动流性能研究

Evaluation of ultramicroporous expanded polytetrafluoroethylene mitral valve under pulsatile flow condition in vitro

目的对自行研制的25#和27#四瓣叶、无支架、带腱索人工二尖瓣-超微孔膨体聚四氟乙烯人工心脏瓣膜(UPMV)进行体外脉动流检测,了解其体外脉动流力学特征。方法连续制作的25#UPMV和27#UPMV各6例使用TH-1200型人工心脏瓣膜体外脉动流试验台检测,循环率为70cycle/min。结果在流量为2、3、4、5、6L/min时,25#UPMV在体外脉动流下的平均跨瓣压差分别为(2.488±0.378)、(4.427±0.240)、(5.460±0.449)、(6.776±0.391)、(8.327±0.490)mmHg;有效瓣口面积分别为(1.430±0.333)、(1.993±0.208)、(2.260±0.477)、(3.204±0.174)、(3.652±0.158)cm2;返流百分比分别为(5.731±0.643)、(5.431±0.312)、(5.059±0.708)、(3.545±0.097)、(2.615±0.125)%。27#UPMV在体外脉动流下的平均跨瓣压差分别为(1.618±0.497)、(3.448±0.440)、(4.825±0.434)、(5.494±0.446)、(7.482±0.455)mmHg;有效瓣口面积分别为(1.773±0.364)、(2.113±0.305)、(2.409±0.295)、(3.326±0.417)、(4.522±0.445)cm2;返流百分比分别为(5.357±0.509)、(5.407±0.110)、(4.999±0.182)、(4.010±0.254)、(2.584±0.114)%。结论25#和27#UPMV在体外脉动流下的平均跨瓣压差、有效开口面积和返流百分比均符合国家标准。

Objective To test 25# and 27# ultramicroporous expanded polytetrafluo-roethylene mitral valve （UPMV） under pulsatile flow condition in vitro. Methods Six 25# and six 27#UPMV were tested using TH-1200 I-IV Prosthesis Pulsatile Flow Tester in vitro at the cycling rate of 70 cycle/min, with the systolic pressure maintained at about 16 kPa （120 mmHg）, diastolic pressure at 10.7 kPa （80 mmHg）, and the percentage of mean forward flow at 35%. The stimulant cardiac output was maintained at 2, 3, 4, 5 and 6 L/min, respectively, for the testing. Results The mean pressure difference for the 25#UPMV under stimulant cardiac output of 2, 3, 4, 5 and 6 L/min was 2.488±0.378, 4.427±0.240, 5.460±0.449, 6.776±0.391 and 8.327± 0.490 mmHg, and its effective valvular orifice was 1.430±0.333, 1.993±0.208, 2.260±0.477, 3.204±0.174 and 3.652±0.158 cm^2, respectively. The regurgitant fraction of the 25#UPMV under each stimulant cardiac output was （5.731 ±0.643）%, （5.431 ± 0.312）%, （5.059 ±0.708）%, （3.545 ±0.097）% and （2.615 ±0.125）%, respectively. The mean pressure difference of the 27# UPMV under each stimulant cardiac output was 1.618±0.497, 3.448±0.440, 4.825±0.434, 5.494±0.446 and 7.482±0.455 mmHg, effective valvularorificewas 1.773±0.364, 2.113±0.305, 2.409±0.295, 3.326±0.417and4.522±0.445cm2, and regurgitant fi-action was （5.357±0.509）%, （5.407 ±0.110）%, （4.999±0.182）0A, （4.010±0.254）% and （2.584±0.114）%, respectively. Conclusion The mean pressure difference, effective valvular orifice and regurgitant fraction of the UPMVs can measure up to the national criteria for artificial heart valve prosthesis of China.