银杏叶提取物对儿童肾病综合征高脂血症的影响

Therapeutic effect of Ginkgo biloba leaf extract on hypercholestrolemia in children with nephrotic syndrome

目的探讨银杏叶提取物对原发性肾病综合征(NS)患儿高脂血症的治疗效果。方法将我科2000年10月～2005年10月收治的35例小儿NS随机分为两组:治疗组(银杏叶)18例,采用强的松加银杏叶提取物(银杏叶片)治疗;对照组(双嘧达莫)17例,采用强的松加双嘧达莫治疗。8周为一疗程,疗程结束后判断疗效,分别于治疗前后观察临床症状和血液生化检验指标的变化。结果治疗8周后临床症状及血液生化指标等明显改善,两组治疗前后比较有显著性差异(P<0.01),24h尿蛋白定量下降(P<0.05);两组血脂指标明显改善(P<0.05),治疗组明显优于对照组。结论银杏叶提取物(银杏叶片)对NS患儿高脂血症治疗有明显疗效,具体为可改善临床症状、减少蛋白尿、降低高血脂及具有保护肾功能等作用,配合激素治疗具有临床应用价值。

Objective To explore the therapeutic effects of the extract of Ginkgo biloba leaf on hypercholestrolemia in children with primary nephritic syndrome （NS）. Methods Thirty-five children with NS were randomized into 2 groups for treatment with prodnisone plus Ginkgo biloba leaf extract （18 cases） or with prednisone plus dipyridamole （17 cases） for 8 weeks. After completion of the treatments, the therapeutic effects were evaluated and the changes in the blood biochemical markers assayed. Results The 8-week treatment with the extract significantly ameliorated the clinical symptoms and blood biochemistry as compared with prednisome plus dipyridamole group （P〈0.01）. The levels of urinic protein and blood lipid in Ginkgo leaf group were significantly lower than those in prednisome plus dipyridamole group （P〈0.05）. Conclusion The extract from Ginkgo biloba leaf can lower blood lipid levels and urinic protein in children with NS and improve their clinical syptoms and the renal function, therefore has much clinical value as an adjuvant treatment of steroid therapy in such children.