能转化鹅去氧胆酸为熊去氧胆酸的厌氧菌的筛选

THE ISOLATION OF ANAEROBES CAPABLE OF BIOTRANSFORMING CHENODEOXYCHOLIC ACID TO URSODEOXYCHOLIC ACID

熊去氧胆酸(ursodeoxycholic acid,UDCA)是熊胆的主要成分,也是治疗胆固醇结石的有效药物。本文采用自行设计的“针筒法”,从640份土样中筛出三株具有较高转化鹅去氧胆酸(chenodeoxycholic acid,CDCA)为UDCA能力的厌氧梭茵,并发现它们单独都具有UDOA生物转化能力。

Ursodeoxycholic acid (UDCA), an effective and expensive medicine for trea-ting cholelithiasis, occurs in high concentration in the bile of bears. Using the'syringe method' designed by us, three strains of clostridia which transformedchenodeoxycholic acid (CDCA) to UDCA efficiently under anaerobic conditionswere isolated from 640 soil samples. It was found that they were capable ofconversing CDCA to UDCA independently.