激光泪道成形术联合丝裂霉素C治疗泪道阻塞

Intraoperative Mitomycin C in Laser Dacryoplasty

目的探讨丝裂霉素C(MMC)在Nd∶YAG激光泪道成形术中的疗效。方法将308例(398只眼)泪道阻塞患者随机分为对照组和治疗组,治疗组158例(210只眼)采用常规激光泪道成形术后将0.2ml丝裂霉素C注入泪道5 min后应用抗生素眼膏填充泪道,对照组150例(188只眼)采用常规激光泪道成形术,术毕应用抗生素眼膏填充泪道。结果术后随访6～36个月,平均24个月,治疗组治愈率为87.1%,总有效率为95.7%;对照组治愈率为78.2%,总有效率为83.0%。对照组疗效低于治疗组(P<0.05)。结论在泪道激光成形术中应用MMC可有效减少激光术后纤维组织增殖和瘢痕形成,提高远期疗效。

Objective To assess the efficacy of mitomycin C（MMC） in Nd：YAG laser dacryoplasty. Methods Three hundred ninety eight eyes in 308 cases with obstruction of lacrimal passage were randomly divided into MMC group and control group. In MMC group, 210 eyes of 158 cases firstly applied 0. 2 ml MMC for 5 min,then filled up antibiotic ointment. In control group, 150 cases （188 eyes） rifled up only antibiotic ointment without MMC. Results All patients were followed up for 6-36 months. It was found that the cure rate and effective rate of MMC group were 87. 1% and 95.7% ,and the rates of control group were 78.2% and 83.0% which were less than the rates of MMC group（ P 〈0. 05）. Conclusions Using MMC in YAG laser dacryoplasty can effectively inhibit the scar formation, and provide a higher successful rate of laser daeryoplasty.