摘要
高CO2血症是肺保护性通气策略的一个重要组成部分。临床证据支持了容许性高CO2血症在急性肺损伤／急性呼吸窘迫综合征（ALI／ARDS）患者中的应用。动物实验也证明治疗性高CO2血症可减轻缺血／再灌注、机械通气、内毒素所致的肺损伤。高CO2血症可在多个方面影响ALI／ARDS的病理生理，免疫功能及细胞分子水平的变化。
Hypercapnia is a central component of current protective ventilatory strategies. Increasing clinical evidence supports the use of permissive hypercapnia, particularly in acute lung injury/acute respiratory distress syndrome. Recent experimental studies provide further support for the concept of therapeutic hypercapnia, which deliberately elevated PaCO2 may attenuate experimental acute lung injury because of mesenteric ischemia reperfusion, ventilator-induced and pulmonary endotoxin instillation. Hypercapnic acidosis has a multitude of effects at the pathologic and physiopathologic characteristic, immunologic function, cellular and molecular level of ALI/ARDS.
出处
《国际麻醉学与复苏杂志》
CAS
2007年第2期187-190,共4页
International Journal of Anesthesiology and Resuscitation
