低分子质量肝素钙治疗肝硬化性黄疸疗效及安全性

Effect of Low Molecular Weight Heparin on Jaundice in Liver Cirrhotic Patients and Safety Evaluation

目的观察低分子肝素钙治疗肝硬化性黄疸的疗效;规范护理程序,提高肝素治疗的安全性。方法通过对难治性肝硬化性黄疸患者在常规治疗基础上加用低分子质量肝素治疗3周,定期复查肝功能,记录皮下出血、疼痛数值;结合临床实践经验和体会,提炼出肝硬化性黄疸的护理要点。结果在降低血清总胆红素方面,两种肝素治疗组均优于常规治疗组(P<0·05);选用低分子肝素钙皮下注射的方法,较低分子肝素钠显著降低了皮下出血及疼痛。结论常规治疗联合国产低分子质量肝素钙退黄疗效确切,安全性高,对病人痛苦少,值得推广使用。

Objective To evaluate the effect of low molecular weight heparin（LMWH） calcium on jaundice in the treatment of liver cirrhotic patients and set up the nursing principles to Guarantee the safety of heparin therapy. Methods A prospective randomized controlled clinical study on the treatment of liver cirrhotic patients with hepatitis B was performed. 75 patients were randomly divided into three groups ; （ 1 ） Conventional treatment group （ n = 15 ） ; （ 2 ） Conventional treatment plus LMW H sodium treatment group （ n = 30 ）. （ 3 ） Conventional treatment plus LMWH calcium treatment group（ n = 30）. The clinical parameters and treatment results in the 3 groups were compared. The nursing principles of heparin therapy for liver cirrhosis was performed. Results After treatment, level of serum Tbil in LMWH treatment group was significantly decreased （P 〈 0.05 ）, compared with Conventional treatment group, less Hypodermic hemorrhage and less pain were found while LMWH calcium using. Conclusions LMWH in combination with conventional treatment for liver cirrhotic patients, significantly improves the outcome , Domestic LMWH calcium is a safe and effective drug.