血管紧张素转换酶抑制剂抗肿瘤作用研究进展

Advances in angiotensin converting enzyme inhibitors for cancer treatment

血管紧张素转换酶抑制剂（ACEI）是临床上常用的抗高血压药物，近年来，越来越多的研究发现它们还具有抗肿瘤的作用，ACEI类药物可能通过抑制血管内皮生长因子（VEGF）、基质金属蛋白酶（MMP）的表达，增加血管抑素的生成等多个方面发挥其抗肿瘤作用。其临床相对优良的安全性可能为抗肿瘤治疗提供新的策略。

Angiotensin converting enzyme inhibitor （ACEI） is commonly used as antihypertensive agents. Recently several experimental studies demonstrate the effect of ACEI on anti-cancer. The possible mechanisms may include inhibition of matrix metalloproteinase activity , reduced expression of vascular endothelial growth factor and increased expression of angiostatin. Since ACEI is already in widespread clinical use without any serious adverse effects,it may represent a potential new strategy for cancer therapy.