上海地区汉族人群肝细胞癌与HLA-DRB1*17等位基因遗传易感性相关的研究

Association between hepatocellular carcinoma and HLA-DRB1*17 alleles in Shanghai Hanpopulation

目的探讨上海地区汉族人群乙型肝炎并发肝细胞癌与HLA-DRB1位点的相关性。方法采用基因芯片分型方法,检测56例慢性乙型肝炎患者、61例乙型肝炎肝硬化患者及33例乙型肝炎并发肝细胞癌患者的HLA-DRB1基因分型,并与146例正常人的结果进行比较。结果HLA-DRB1*17位点的频率在乙型肝炎并发肝细胞癌组明显升高,与正常组、慢性乙型肝炎组及乙型肝炎肝硬化组比较差异有统计学意义(均P<α′)。结论HLA-DRB1*17基因与上海汉族人群乙型肝炎并发肝细胞癌的发生有一定相关性。

Objective To investigate the relationship between hepatocellular carcinoma and HLA-DRB1 alleles in Shanghai Han population. Methods HLA-DRB1 genotypings were determined in 56 patients with chronic hepatitis B, 61 patients with post-hepatitis B-cirrhosis, 33 patients with hepatocellular carcinoma due to chronic hepatitis B and 146 healthy controls by DNA chips. All patients belonged to Han ethnicity from Shanghai area. Results The frequency of HLA-DRBI＊17 alleles in the hepatocellular carcinoma group was higher than that in other groups. Conclusion HLA-DRB1 ＊ 17 alleles might be associated with the susceptibility to hepatocellular carcinoma in Shanghai Han population.