期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

动脉血栓性疾病抗活化蛋白C和凝血因子Ⅴ基因突变的研究 被引量：1

Gene Mutation Study of activating protein C resistance and Acv in arterial thrombosis
下载PDF
导出
摘要 引起动脉血栓形成的病因很多,其中抗活化蛋白C现象是至今所知的最主要的原因,APCR是到目前为止人们所发现的发生率最高的血栓风险因素,APCR和FⅤ Leiden存在地区种属差异。本文主要就动脉血栓形成与APCR进行综述。 Arterial thrombosis is caused by many reasons,among which activating protein C resistance （APCR） is one of most important reasons known nowadays.APCR also is the highest thrombotic risk factor with the highest incidence rate. APCR and FV Leiden mutation is varied according to different regions and races. This article reviews arterial thrombosis and APCR.
作者 高丽霞 哈力代 温丙昭
机构地区 新疆医科大学第一附属医院血液科
出处 《医学综述》 2007年第9期665-667,共3页 Medical Recapitulate
关键词 动脉血栓 抗活化蛋白C现象 凝血因子V 基因突变 Arterial Thrombosis： Activating protein C resistance： FV Leiden gene mutation
分类号 R543.5 [医药卫生—心血管疾病]
  • 相关文献

参考文献20

  • 1Dahiback B,Carlsson M,Svensson PJ.Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein:prediction of a cofactor to activated protein C[J].Proc Natl Acad Sci USA,1993,90(3):1004-1008.
  • 2Zoller B,Frutos PG,Hillarp A,et al.Thromophilia as a multigenic disease[J].Haematologica,1999,84(1):59-70.
  • 3Bokarewa MI,Bremme K,Falk G,et al.Studies on phospholipids antibodies,APC2 resistance and associated mutation in the coagulation factor Ⅴ gene[J].Thromb Res,1995,78(3):193-200.
  • 4Bertina RM,Koeleman BP,Koster T,et al.Mutation in blood coagulation factor Ⅴ associated with resistance to activated protein C[J].Nature,1994,369(6475):64-67.
  • 5Ehenforth S,Radtke KP,Scharrer I,et al.Acquired activated protein C-resistance in patients with lupus anticoagulants[J].Thromb Haemost,1995,72(2):797-798.
  • 6储海燕,诸江,王鸿利,邵慧珍,张庆华,张宇舟,王学锋,杨景文,陈竺,王振义.上海地区深静脉血栓形成患者抗活化的蛋白C及FⅤLeiden突变的初步调查[J].中华血液学杂志,1996,17(9):462-465. 被引量：34
  • 7Wu JS,Gu JM,Xu J,et al.Factor Ⅴ Leiden mutation in one family of Chinese origin[J].Chin Med J,2001,114:379-388.
  • 8李家增.血栓形成机制[J].临床内科杂志,2004,21(12):793-795. 被引量：31
  • 9Allaart CF,Briet E.Familial venous thrombophilia[A].Bloom AL.Forbes CD,Thomas Dp,et al(eds).Haemostasis and Thrombosis[M].3rd ed.London,UK:Churchill Livingstone,1994.1349.
  • 10Poort SR,Rosendaal FR,Reitsma PH,et al.Acommon genetic variation in the 32 untranslated region of the pro thrombin gene is associated with elevated plasma pro thrombin levels and an increase in venous thrombosis[J].Blood,1996,88(10):3698-3703.

二级参考文献31

  • 1程志强,蔡军,蔡芳,赵崇,张镜宇,张连祥,张建民,郑翠英.适于临床PCR法基因检测的血样处理[J].天津医科大学学报,1996,2(2):18-20. 被引量：14
  • 2储海燕,诸江,王鸿利,邵慧珍,张庆华,张宇舟,王学锋,杨景文,陈竺,王振义.上海地区深静脉血栓形成患者抗活化的蛋白C及FⅤLeiden突变的初步调查[J].中华血液学杂志,1996,17(9):462-465. 被引量：34
  • 3Sun X，Blood，1994年，83卷，3120页
  • 4Greengard J S，Lancet，1994年，343卷，1361页
  • 5Giffin J, Heeb MJ, Kojima Y, et al. Activated protein C resistence: molecular mechanisms.Thromb Haemost, 1995,74: 444-448.
  • 6Longstreth WT, Roesndaal FR, Siscovick DS, et al.Risk of stroke in young women and two prothrombotic mutations: factor V Leiden and prothrombin gene variant (G20210A).Stroke, 1998, 19: 577-580.
  • 7Tanne D, D'Olhaberriague L, Schultz LR, et al.Anticardiolipin antibodies and their associations with cerebrovascular risk factors.Neurology, 1999, 52: 1368-1373.
  • 8Amer L, Kisiel W, Searles RP, et al.Impairment of the protein C anticoagulant path in a patient with systemic lupus erythematosus, anticardiolipin antibodies and thrombosis.Thromb Res, 1990, 57: 247-258.
  • 9Voorberg J, Roelse J, Koopman R, et al.Association of idiopathic venous thromboembolism with single point mutation at Arg506 of factor V.Lancet, 1994, 343:1535-1536.
  • 10Shen MC, Lin JS, Tasy W, et al.High prevalence of antithrombon Ⅲ, protein C and protein S deficiency, but no factor Ⅴ Leiden mutation in venous thrombophilic Chinese patients in Taiwan.Thromb Res, 1997,87:377-385.

共引文献81

同被引文献7

  • 1储海燕,诸江,王鸿利,邵慧珍,张庆华,张宇舟,王学锋,杨景文,陈竺,王振义.上海地区深静脉血栓形成患者抗活化的蛋白C及FⅤLeiden突变的初步调查[J].中华血液学杂志,1996,17(9):462-465. 被引量：34
  • 2何照洪 周永强 等.Leiden第Ⅴ因子之变异在中国人种中的流行率[J].中华医学杂志（台湾）,1999,62(12):875-878.
  • 3Rigat B, Hubert C, Alhenc-Gelas F, et al. An inser-tion/deleton Polynerphism in the angiotensin Ⅰ-con-vertiug enzyme gene accomating for half the variance of serum enzyme levels. J Clin Invest, 1990,86 (4) : 1343-1346.
  • 4Svensson PJ, Dahlback B. Resistance to activated protein C as a basis for venous thrombosis J. N Engl J Med,1994,330(8) :517-522.
  • 5Folsom AR, Cushman M, Tsai MY, et al. A prospective study of venous thromboembolism in relation to factor V Leiden and related factors. Blood, 2002,99(8) :2 720.
  • 6Irani-Hakime N, Tamim H, Elias G,et al. Factor V RS06Q mutation- Leiden : an independent risk factor for venous thrombosis but not coronary artery disease. Thromb Thrombolysis, 2001,11 (2) :111.
  • 7李凤芹,杨志刚,刘国勋,凌光鑫,蔡望伟,谢朝阳,杨勤.粤西籍人群Fv Leiden基因突变的初步调查[J].广东医学院学报,2000,18(2):122-123. 被引量：3

引证文献1

医学综述
2007年 第9期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部