摘要
过氧化物酶体增殖物激活受体(PPAR-γ)是核受体超家族成员之一,通过PPAR-γ激活剂特异激活,促进脂肪细胞分化,增加胰岛素敏感性,在胰岛素抵抗、动脉粥样硬化、糖尿病等代谢性疾病的发生、发展及防治过程中扮演重要角色。脂联素是脂肪细胞分泌的一种细胞因子,通过结合脂联素受体——AdipoR1和AdipoR2发挥抗炎、抗糖尿病、抗动脉粥样硬化的作用。PPAR-γ激活剂在动物以及人体中可均增加脂联素的水平,并对脂联素复合物、脂联素受体产生影响。通过对PPAR-γ激活剂对脂联素以及脂联素受体可能作用机制的阐述,对于糖尿病和动脉粥样硬化的治疗具有积极的临床意义。
PPAR gamma is one of key nuclear receptors superfamily, which can be specific activated by its agonist and play an important role in promoting fat cell differentiation, incresing insulin sensitivity as well as in the occurrence, development and prevention of metabolic diseases including insulin resistance, atherosclerosis, diabetes and so on ,Adiponectin is a cytokine secreated by fat cells,which can exert its effect on anti-inflammatory, anti-diabetes and anti-atherasclerosis by binding adiponectin receptor. PPAR gamma agonist can increase the level of adiponectin and affect adiponectin complex and adiponectin receptor. This article reviews the active mechanism of PPAR-γ agonist on adiponectin and its receptor, which has a positive significance in the treatment of diabetes and atheroscleresis.
出处
《医学综述》
2007年第9期669-671,共3页
Medical Recapitulate
