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HIV-1膜蛋白抗原优化改造研究进展

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摘要 HIV-1的外膜糖蛋白能与T细胞或单核／巨噬细胞表面的CD4受体分子结合，从而起始HIV感染靶细胞的生物学过程。由于HIV-1膜蛋白是中和抗体的主要作用靶位，因此成为HIV疫苗中不可缺少的组分。越来越多的研究表明：天然HIV-1膜蛋白不能激发有效的中和抗体，所以需要对膜蛋白进行优化改造，以提高中和表位的免疫原性。本文就近年来HIV-1膜蛋白抗原优化改造研究做一简要回顾以供参考。
作者 万延民（综述） 吴岚 徐建青 邵一鸣（审校）
机构地区 中国疾病预防控制中心性病艾滋病预防控制中心
出处 《国际病毒学杂志》 2007年第2期49-54,共6页 International Journal of Virology
关键词 HIV膜蛋白 疫苗 中和抗体 抗原改造
分类号 R382.5 [医药卫生—医学寄生虫学]
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参考文献48

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国际病毒学杂志
2007年 第2期

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