摘要
肾素-血管紧张肽系统(RAS)是药物治疗心血管系统疾病的关键作用靶点。目前的主要药物是血管紧张肽转化酶抑制剂(ACEI)和血管紧张肽Ⅰ受体拮抗剂(ARBs),因此被认为是作用于RAS治疗心血管疾病的经典药物,但是还有许多能够通过其他途径而产生对RAS的抑制作用。本文综述了目前发现的一些其他途径以及和经典途径的联系以及阻断它们产生的可能效应,包括ACEI抑制剂、ARBs、肾素抑制剂、糜蛋白酶抑制剂、血管紧张肽转化酶2、中性肽链内切酶抑制剂、醛固酮抑制剂以及针对RAS的基因治疗和免疫治疗。
The rennin-angiotensin-aldosterone system（RAS） is a key target for drugs combating cardiovascular disease, at which the targeted drugs are. Angiotensin-converting enzyme inhibitors （ACEI） and angiotensin receptor type-1 （ATI receptor） blockers（ARBs） Although there are many other drugs which can exert its inhibitory effect on RAS by any other pathway,both of these two drugs can be considered to be the classical drugs in treating cardiovascular diseases by acting on RAS. This article reviews some other pathways and their relationship with classical pathway as wellas their possible efficacy once being blocked, including ACEI, ARBs, Renin inhibitors, Chymase inhibitors, Angiotensin-converting enzyme 2 （ACE2）, Neutral endopeptidase inhibitors, Aldosterone inhibitors and gene therapy and immunotherapy aiming at RAS.
出处
《医学综述》
2007年第10期782-784,共3页
Medical Recapitulate
