尿毒症患者红细胞膜阴离子通透性的异常

ABNORMALITY OF ANION TRANSPORT ACROSS THE ERYTHROCYTE MEMBRANE IN UREMIA PATIENTS

对16例尿毒症患者的红细胞样品进行了阴离子跨膜通透特性的研究,发现患者红细胞膜的阴离子NO_2^-速率比正常的减慢了约一半。统计检验表明,减慢程度和患者血液中尿素氮、肌酐的含量有显著相关性。用对阴离子运输有专一性抑制的4,4′一二硫氰基-2,2′一二磺基芪实验表明,患者红细胞膜对NO_2^-通透性的异常,很可能与带3蛋白细胞外侧片断受到的损伤有关。

The anion transport across the erythrocyte membrane in 16 uremia patientswas studied. It was found that the NO_2^- transport rate across erythrocyte membranein patients slowed down to half level as compared with the normal. The statisticaltest showed that the relationship between decrease extent and the amount of bloodurea nitrogen or creatinine was significant. By using a specific inhibitor of aniontransport, DIDS, it was shown that the abnormality of NO_2^- transport across theerythrocyte membrane in patients is due probably to a damage of extracellulardomain of band 3 protein.