栀子对大鼠肝肾毒性的病理学观察

The Pathological Observation of Toxicity on Kidney and Haper by Fructus Gardeniae in Rats

目的:观察栀子不同提取物所致的大鼠肝、肾病理学变化。方法:灌胃给药3 d后,解剖大鼠,肝、肾组织称重,福尔马林固定,HE染色,光镜下病理学观察。结果:栀子水提物、醇提物、京尼平苷大剂量组肝重量增加,指数增大,与空白组相比(P<0.001),肾脏重量轻度增加;光镜下可见各给药大剂量组肝细胞明显肿胀变性,部分肝细胞坏死,汇管区有大量的毛细胆管增生;肾曲管不同程度肿胀。结论:大剂量的栀子水提物、醇提物及京尼平苷导致明显的肝、肾病理学改变,具有肝、肾毒性。

Objective：To study the toxicity of kidney and haper by Fructus Gardeniae in rats. Method： Mter administration for 3days, rats were executed, the samples of liver and kidney were collected and weighted, the pathological observation was carried out by optical microscope. Result： The organ relative weight of liver and kidney increased, compared with control group（ P 〈 0.001 ）, the tumefaction and necrosis of hepatic ceils with proliferation of capillary in portal area were found, there was tumefaction in the trenal tubules. Conclusion： Fructus Gardeniae can result in the toxicity of haper and kidney in rats.