摘要
目的:观察栀子不同提取物所致的大鼠肝、肾病理学变化。方法:灌胃给药3 d后,解剖大鼠,肝、肾组织称重,福尔马林固定,HE染色,光镜下病理学观察。结果:栀子水提物、醇提物、京尼平苷大剂量组肝重量增加,指数增大,与空白组相比(P<0.001),肾脏重量轻度增加;光镜下可见各给药大剂量组肝细胞明显肿胀变性,部分肝细胞坏死,汇管区有大量的毛细胆管增生;肾曲管不同程度肿胀。结论:大剂量的栀子水提物、醇提物及京尼平苷导致明显的肝、肾病理学改变,具有肝、肾毒性。
Objective:To study the toxicity of kidney and haper by Fructus Gardeniae in rats. Method: Mter administration for 3days, rats were executed, the samples of liver and kidney were collected and weighted, the pathological observation was carried out by optical microscope. Result: The organ relative weight of liver and kidney increased, compared with control group( P 〈 0.001 ), the tumefaction and necrosis of hepatic ceils with proliferation of capillary in portal area were found, there was tumefaction in the trenal tubules. Conclusion: Fructus Gardeniae can result in the toxicity of haper and kidney in rats.
出处
《中国实验方剂学杂志》
CAS
2007年第5期45-48,共4页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家科技基础条件平台项目(2004DEA71170)
科研院所社会公益研究专项(2004DIB2J062)
关键词
栀子
肝脏
肾脏
病理
Fructus Gardenia
haper
kidney
pathology