高血压患者超重和非超重与心血管病危险性的关系

Risk in cardiovascular diseases for overweight and nonoverweight hypertensives

本研究以３０５０例来自人群流行病学调查所得高血压患者［收缩压≥１４０ｍｍＨｇ（１ｍｍＨｇ＝０．１３３ｋＰａ），舒张压≥９０ｍｍＨｇ或在二周内服用降压药者］作为研究对象，按体重指数（ＢＭＩ）＜２５ｋｇ／ｍ２和ＢＭＩ≥２５ｋｇ／ｍ２分为非超重高血压组和超重高血压组。研究结果表明：超重高血压组平均ＳＢＰ、ＤＢＰ、血清总胆固醇（ＴＣ）、血糖水平和家族史阳性率均明显高于非超重高血压组，而血清高密度脂蛋白胆固醇（ＨＤＬ－Ｃ）水平则明显低于非超重高血压组，并发心血管疾病者也显示多于非超重高血压组的倾向。上述结果说明：尽管在我国人群超重以轻中度为主，但合并超重的高血压者较不合并超重的高血压者具有更大的发生心血管病的危险。在临床实际工作中，合并超重的高血压患者应积极减重，并控制在正常范围。这一点对于预防冠状动脉粥样硬化性心脏病等心血管病是至关重要的。

Objective :To compare cardiovascular disease risk between overweight and nonoverweight hypertensives.Method:A total of 3 050 hypertensives (SBP≥140 mmHg, DBP≥90 mmHg or on medication in 2 weeks) from a community based large multicenter epidemiology survey were divided into overweight (BMI≥25 kg/m 2) and non overweight (BMI<25 kg/m 2) for a comparison in cardiovascular risk factors. Results: For overweight hypertensives, mean SBP, DBP, TC, blood glucose and prevalence of positive family history of cardiovascular diseases were significantly higher, whereas mean HDL C was significantly lower than nonoverweight hypertensives. Prevalence of cardiovascular complications tended to be higher for overweight hypertensives than for nonoverweight hypertensives too.Conclusion : The results indicate that overweight hypertensives are more subjected to having cardiovascular diseases than nonoverweight hypertensives. In clinical practice, overweight hypertensives should be recommended to lose body weight and control to normal range. This is of great importance in prevention of atherosclerostic heart disease.(1mmHg=0.133kPa)