重组链激酶对犬冠状动脉栓塞的作用

Effects of recombinant streptokinase on coronary thrombotic occlusion in canine

本研究用２６只犬，分成５组分别为：生理盐水（ＮＳ）对照组、重组链激酶（ｒ－ＳＫ）１５０００ＩＵ／ｋｇ组、ｒ－ＳＫ３００００ＵＩ／ｋｇ组、ｒ－ＳＫ６００００ＵＩ／ｋｇ组及阳性对照链激酶（ＳＫ）３００００ＵＩ／ｋｇ组，以观察ｒ－ＳＫ的溶栓作用。在犬冠状动脉左前降支分支插管导入血栓后，心电图ＳＴ段抬高，心率明显减慢，冠状动脉造影见冠状动脉断流。用ｒ－ＳＫ后，栓塞引起的ＳＴ段抬高缓解，但心率无明显变化。冠状动脉造影的结果表明，随着ｒ－ＳＫ的剂量升高栓塞溶解的犬数增加。血液生化指标显示ｒ－ＳＫ对凝血时间和凝血酶原时间无影响，延长优球蛋白溶解时间，但降低纤溶酶原含量，增加Ｄ二聚体的含量。与ＮＳ组比较，ｒ－ＳＫ组心肌梗死面积明显减小。本研究证明静脉注射ｒ－ＳＫ能溶解犬冠状动脉栓塞。

The effects of different doses of recombinant streptokinase (r SK) on canine coronary thrombotic occulsion were studied. Twenty six dogs were divided into five groups: the negative controlnormal saline solution (NS) group, r SK 15 000UI/kg group, r SK 30 000UI/kg group, r SK 60 000UI/kg group, and positive control SK 3 000 UI/kg group. After inducing thrombi (human plasma+fibrinogen+thrombase after coagulating for an hour) into a diagonal branch of the left anterior descended on the coronary angiogram. In r SK treated groups the elevated ST segment restored but heart rate did not change significangly. The coronary angiograms showed that r SK dissolved the voronary thrombi. The number of the canine with thrombolysis increased with the doses of r SK. The r SK did not influence clot time and prothrombin time, but prolonged the euglobulin clot lysis time, decreased plasminogen content in blood plasma and increased the D dimer of the fibrin degradation product. The myocardial infarct area was significantly smaller in r SK group than that in NS group. The results of this study proved that recombinant streptokinase given intravenously can dissolve the coronary thrombi.