^(131)I治疗Graves病合并周期性麻痹48例

^(131)I for treatment of 48 patients with Graves disease accompanies periodic paralysis treat

目的探讨131I治疗Graves病合并周期性麻痹的疗效。方法对48例Graves病合并周期性麻痹患者进行131I口服治疗,每克甲状腺组织给予131I治疗剂量为3.70 MBq,于服131I后3个月、6个月、1 a复查血清游离三碘甲状腺原氨酸(FT3)、血清游离甲状腺素(FT4)、血清促甲状腺素(TSH),测定血钾和观察周期性麻痹恢复情况。结果治疗后3个月、6个月及1a Graves病总治愈率为72.9%、95.8%、100%,周期性麻痹总治愈率为58.3%、79.2%、100%。6个月时治愈率明显高于3个月时(χ2=16.294,χ2=14.737,P<0.05)。结论131I治疗Graves病合并周期性麻痹疗效较好,尽快治愈Graves病是控制周期性麻痹发作的关键。

Objective To explore the curative effect of using 131Ⅰ to treat Graves disease accompanies periodic paralysis. Methods Forty-eight cases with Graves disease accompanies periodic paralysis were given 131Ⅰ at a dosage of 3.70 MBq per gram of thyroid tissue. The patients rechecked free tri-iodothyronine index（ FT3 ） ,free thyroxine index（ FT4）, thyroid stimulating hormone（TSH） and potassium kalium in blood and observed condition of periodic paralysis after treatment for three months, six months, and one year respectively. Results After three moths, six moths and one year treatment, 35 cases （72.9%） ,46 cases （ 95.8 % ） and 48 cases （ 100% ） with Graves disease were cured respectively,28 cases （ 58.3 % ）, 38 cases （ 79.2% ） and 48 cases（ 100% ） with periodic paralysis were cured. There was significant difference in the euthyroid rate between three months and six months （X^2 = 16. 294 ,X^2 = 14.737, P 〈 0.05 ）. Conclusion The effect of using 131Ⅰ to treate Graves disease accompanies periodic paralysis is good. Curing Graves disease is the key to control periodic paralysis.