摘要
目的探讨巨细胞病毒PP65抗原(CMV-PP65)检测在肾移植术后患者巨细胞病毒病防治中的价值。方法肾移植术后患者37例,常规随诊接受巨细胞病毒PP65抗原检查。结果37例患者中11例(29.7%,11/37)CMV-PP65抗原阳性,均给予更昔洛韦抗病毒治疗,11例患者中3例(8.1%,3/37)发展成巨细胞病毒病,均发生于停用或未采用更昔洛韦时;另外26例患者(70.3%,26/37)PP65抗原始终阴性,随访3个月无巨细胞病毒病。结论巨细胞病毒PP65抗原检测对于肾移植术后巨细胞病毒病的诊断、治疗尤其是预防起到重要作用。
[Objective] To study the value of cytomegalovirus PP65 antigen detection in the prophylaxis and treatment of cytomegalovirus disease after renal transplantation. [Methods] A study was conducted in 37 cases of renal allograft recipients. Patients received CMV-PP65 antigen detection regularly. [Results] Eleven patients （29.7%, 11/37） were CMV-PP65 antigen positive and had to receive anti-virus treatment with ganciclovir. Three patients developed to CMV disease and all the 3 cases happened when ganciclovir were withdrawed. Other 26 patients （70.3%, 26/37） were CMV-PP65 antigen negative anytime and no CMV disease happened during 3 months＇ followup. [Conclusion] Cytomegalovirus PP65 antigen detection in renal allograft recipients played an important role in the diagnosis, treatment and especially the prophylaxis of CMV disease.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2007年第9期1081-1083,共3页
China Journal of Modern Medicine
关键词
肾移植
巨细胞病毒
更昔洛韦
renal transplantation
cytomegalovirus
ganciclovir
