Ni催化Suzuki反应的研究进展

Progress of Ni-catalyzed Suzuki reaction

综述了近年来镍催化的Suzuki偶联反应的研究进展。回顾了各类卤代芳香烃、磺酸芳基酯、有机硼等底物参与的Suzuki反应在反应条件方面的改进,随着催化剂、配体、还原剂的活性提高,反应条件越来越温和。比较了镍催化剂与钯催化剂的催化能力,镍催化剂向着稳定、高效、价廉的方向发展,且比钯催化剂适用范围广,是钯催化剂的理想替代品。介绍了新型的含氮杂环卡宾及非均相镍催化剂的发展现状及其特点。

The progress of Ni-catalyzed Suzuki cross-coupling reaction is reviewed. For all kinds of haloarenes, arene sulfonates and organoborates, with the enhancement of the activity catalyst, ligand and reducing agent, the reaction conditions become milder. The catalytic capacities of Pd catalyst and Ni catalyst are compared, and Ni catalyst is found to become more stable, effective and cheap. Furthermore, Ni catalyst can catalyze more substrates, hence, it is an ideal substitute of Pd catalyst. Lastly, the development of Ni catalyst of heterocyclic carbenes, heterogeneous catalyst and their advantages are summarized.