早期胃癌在体固有荧光光谱特征分析

Analysis of in vivo autofluorescence spectra in early gastric cancer

目的在体收集早期胃癌病例的胃黏膜固有荧光光谱,初步探索早期胃癌的固有荧光光谱特征。方法通过胃镜活检孔道在体实时收集12例早期胃癌患者胃部病灶和自身正常黏膜的固有荧光光谱,比较两者在400～700nm波长范围内的固有荧光强度。结果12例早期胃癌患者在400～550nm波长段癌灶固有荧光强度明显低于自身正常黏膜。癌肿浸润至黏膜层病例和浸润至黏膜下层病例的固有荧光强度无显著差异。结论400～550nm波段早期胃癌黏膜固有荧光强度明显低于正常黏膜,可能是早期胃癌的固有荧光光谱特征。该波段特征与早期胃癌浸润深度可能无关。

Objective To gather in vivo autofluorescence spectra of gastric mucosa and explore preliminarily the character of spectra in patients with early gastric cancer. Methods In vivo real-time autofluorescence spectra of cancer lesions and normal mucosa in 12 patients with early gastric cancer were gathered through gastroscope biopsy channel, and the autofluorescence intensity of them between the wavelength of 4,00 nm and 700 nm was compared. Results The autofluorescence intensity between the wavelength of 4,00 nm and 550 nm of cancer was significantly lower than that of normal mucosa. No significant difference in autofluorescence intensity exists between mucosa involved and submucosa involved. Conclusion That the autofluorescence intensity of early gastric cancer is lower than that of normal mucosa between the wavelength of 4,00 nm and 550 nm could be the character of early gastric cancer, It may have no relationship with the depth of tumor invasion in the early stage of gastric cancer.