肝硬化患者口服葡萄糖耐量试验的变化

Correlation between oral glucose tolerance test and liver function in cirrhotic patients

目的:探讨口服葡萄糖耐量试验(OGTT)血糖变化与肝硬化患者肝功能状况的关系。方法:肝硬化患者按child-Pugh肝功能分级分为:A级;B级;C级3组,健康人为对照组。行OGTT,采用葡萄糖氧化酶法测定血糖浓度。结果:60min和120min血糖浓度均显著高于对照组(P<0.05),120min血糖与血清白蛋白浓度呈显著负相关(P<0.001),与血清总胆红素浓度、凝血酶原延长时间等呈显著正相关(P<0.001)。结论:OGTT的120min血糖值与肝硬化患者的肝功能状况密切相关,是反映肝硬化患者肝脏处理糖负荷能力的良好指标。

Objective：To investigate the correlation between the change of blood glucose and liver function after oral glucose tolerance test in cirrhotic patients. Methods：36 cirrhotic patients were classified into A,B and C groups according to Child-Pugh score.36 cirrhotic patients and 12 normal controls were given oral glucose tolerance test （OGTT）of 75g glucose after over night fasting. Venous blood samples OGTT 0,30,60,120 and 180 minutes were obtained. Results： The OGTT 60 and 120 minute＇s blood glucose values in total cirrhotic group were significantly higher than that in the controls（P〈0.005）.And the OGTT 60 and 120 minute＇s blood glucose values had an increasing tendency, as liver function got bad. The OGTT 120 minute＇s blood glucose values had a significant correlation with ALB （r=-0.53,P〈0.001）.TBIL （r=-0.43,P〈0.001）.prolonged PT（r=-0.56,P〈0.001 ）. child-Pugh score （r=-0.54,P〈0.001）.Conclusion：The OGTT 120 minute＇s blood glucose values had a significant correlation with liver function in cirrhotic patients.