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幽门螺杆菌尿素通道蛋白研究进展

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摘要 幽门螺杆菌是人类最常见的致病菌,我国普通人群的感染率为50%~80%,而且仍以每年1%~2%的速度增加。H.pylori感染与人B型胃炎和消化性溃疡的发生有密切关系,同时与MALT淋巴瘤和胃癌以及胃肠外疾病也有重要的关系。实验证明H.pylori能够导致蒙古沙鼠胃癌的发生,故已被世界卫生组织国际癌症研究机构列入第一类致癌原。抗生素在H.pylori根除及其相关疾病治疗方面取得了较大进展,但其毒副作用明显、疗效不稳定,
作者 杨丽娟 姜政
出处 《重庆医科大学学报》 CAS CSCD 2007年第6期664-666,669,共4页 Journal of Chongqing Medical University
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  • 1Honda S,Fujioka T,Tokieda M,et al.Development of Helicobacter pylori-induced gastric carcinoma in Mongolian Gerbils[J].Cancer Res,1998;58:4255-4259.
  • 2Park JU,Song JY,Kwon YC,et al.Effect of the urease accessory genes on activation of the Helicobacter pylori urease apoprotein[J].Mol Cells,2005 ;20(3):371-377.
  • 3Weeks DL,Sachs G.Sites of pH regulation of the urea channel of Helicobacter pylori[J].Mol Microbiol,2001 ;40(6):1249-1259.
  • 4Sebbane F,Bury-Mone S,Cailliau K,et al.The Yersinia pseudotuberculosis Yut protein,a new type of urea transporter homologous to eukaryotic channels and functionally interchangeable in vitro with the Helicobacter pylori UreI protein[J].Mol Microbiol,2002 ;45 (4):1165-1174.
  • 5Gueneau P,Loiseaux-De Goer S.Helicobacter:molecular phylogeny and the origin of gastric colonization in the genus[J].Infect Genet Evol,2002; 1 (3):215-223.
  • 6Mollenhauer-Rektorschek M,Hanauer G,Sachs G,et al.Expression of UreI is required for intragastric transit and colonization of gerbil gastric mucosa by Helicobacter pylori[J].Res Microbiol,2002;153(10):659-666.
  • 7Bury-Mone S,Skouloubris S,Labigne A,et al.UreI:a Helicobacter pylori protein essential for resistance to acidity and for the early steps of murine gastric mucosa infection[J].Gastroenterol Clin Biol,2001; 25 (6-7):659-663.
  • 8Sachs G,Shin JM,Munson K,et al.Review article:the control of gastric acid and Helicobacter pylori eradication[J].Aliment Pharmacol Ther,2000; 14(11):1383-1401.
  • 9Rektorschek M,Buhmann A,Weeks D,et al.Acid resistance of Helicobacter pylori depends on the UreI membrane protein and an inner membrane proton barrier[J].Mol Microbiol,2000;36(1):141-512.
  • 10Scott DR,Marcus EA,Weeks DL,et al.Expression of the Helicobacter pylori ureI gene is required for acidic pH activation of cytoplasmic urease[J].Infect Immun,2000;68(2):470-477.

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