黄芪对大鼠酒精性肝病肝组织ICAM-1表达的影响

The Effect of Radis Astragali on the Expression Level of Intercellular Adhesion Molecule-1(ICAM-1) in Liver with Alcoholic Liver Disease in Rats

目的探讨黄芪对大鼠酒精性肝病肝组织ICAM-1的影响。方法将36只大鼠随机分为3组(每组12只):正常对照组(简称对照组)、酒精性肝病模型组(简称模型组)、酒精性肝病黄芪治疗组(简称治疗组)。观察各组肝组织ICAM-1的表达及肝组织形态学改变。结果酒精性肝病模型组肝组织ICAM-1的表达明显增强,与正常对照组有显著性差异(P<0.01);酒精性肝病黄芪治疗组与酒精性肝病模型组比较肝组织ICAM-1的表达明显减弱(P<0.01),肝组织损害减轻(P<0.01)。结论黄芪对酒精性肝病有防治作用,其机理可能与其抑制肝细胞中ICAM-1的的表达有关。

Objective To investigate the effect of Radis Astragali on the expression of intercellular adhesion molecule-1 （ ICAM- 1 ） in liver with alcoholic liver disease in rats. Methods 36 cases of rats were randomly into three groups：control group ,alcoholic liver disease group ,alcoholic liver disease treatment group, 12 cases in each. The morphological changes and ICAM - 1 expression level in liver were observed. Results The expression level of ICAM-1 in alcoholic liver disease group was higher than that in control group（ P 〈 0.01 ）, the structure of liver tissue was impaired（ P 〈 0.01 ）. The expression level of ICAM-1 in alcoholic liver disease treatment group was lower than that in alcoholic liver disease group（ P 〈 0.01 ）, the structure injury in the liver tissue was alleviated （P 〈 0.01 ）. Conclusion Radis Astragali has satisfactory effect on experimental alcoholic liver disease, the mechanism may be corelated with its inhibition on ICAM-1 in liver tissue.