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代谢组学及其在恶性肿瘤研究中的应用 被引量:6

Metabolomics and its application in malignant tumors
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摘要 代谢组学是对某一生物或细胞所有低分子量代谢产物进行定性和定量分析的一门新学科。本文对代谢组学的概念、代谢组学研究的目的和领域以及代谢组学在恶性肿瘤研究中的应用方面进行了综述。 Metabolomics is a new science and technology, which it refers to a holistic analytical approach to all the low molecular weight metabolites in an organism or a cell. In this paper, the definition and objective of metabolomics are provided, and the current application of metabolomic research in malignant tumors (diagnosis and therapy ) are summarized.
出处 《中南大学学报(医学版)》 CAS CSCD 北大核心 2007年第2期221-225,共5页 Journal of Central South University :Medical Science
基金 国家自然科学基金重大项目(30330560) 973重大基础研究前期研究专项(2005CCA03200) 国家重大科学研究计划(2006CB910502 2006CB910504 湖南省卫生厅重大专项(05SK1001-1)~~
关键词 代谢组学 恶性肿瘤 系统生物学 诊断 治疗 metabolomics malignant tumor system biology diagnosis therapy
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  • 1Nicholson J K,Lindon J C,Holmes E.Metabonomics':understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data[J].Xenobiotica,1999,29(11):1181-1189.
  • 2Raamsdonk L M,Teusink B,Broadhurst D,et al.A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations[J].Nat Biotechnol,2001,19(1):45-50.
  • 3Fiehn O,Kopka J,Dormann P,et al.Metabolite profiling for plant functional genomics[J].Nat Biotechnol,2000,18(11):1157-61.
  • 4Taylor J,King R D,Altmann T,et al.Application of metabolomics to plant genotype discrimination using statistics and machine learning[J].Bioinformatics,2002,18(Suppl 2):S241-S248.
  • 5Cairns R,Papandreou I,Denko N.Overcoming Physiologic barriers to cancer treatment by molecularly targeting the tumor microenvironment[J].Mol Cancer Res,2006,4(2):61-70.
  • 6Costello L C,Franklin R B.Why do tumour cells glycolyse? From glycolysis through citrate to lipogenesis[J].Mol Cell Biochem,2005,280(1-2):1-8.(Review)
  • 7Brindle J T,Antti H,Holmes E,et al.Rapid and non-invasive diagnosis of the presence and severity of coronary heart disease using 1H-NMR-based metabonomics[J].Nature Med,2002,8(12):1439 1444.
  • 8Griffin J L,Shockcor J P.Metabolic profiles of cancer cells[J].Nat Rev Cancer,2004,4(7):551-561.
  • 9Tablack P,Sehouli J,Niesporek S,et al.Mass spectrometry-based metabolic profiling reveals different metabolite patterns in invasive ovarian carcinomas and ovarian borderline tumors[J].Cancer Res,2006,66(22):10795-10804.
  • 10Marc M,Gozlan M D.MR Spectroscopy in cancer research and diagnosis.ECCO 13[C].European Cancer Conference,Paris,2005.

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