林州市食管癌和癌前病变检出率的群体对照研究

Comparative study on prevalence rate of cancer and precursor lesions of the esophagus in high-risk populations in Linzhou,China

目的观察林州市高危人群中食管癌和癌前病变的检出率是否降低。方法根据1980年在林州市城郊乡内镜普查527例居民的性别和年龄构成,在同一人群中随机选择与之匹配的人群样本,进行内镜检查和活检病理组织学检查。结果958例受检人群中,检出食管癌、贲门癌32例,检出率3.34%。其中,食管早期表浅癌14例,进展期癌4例;贲门早期表浅癌10例,进展期癌4例。检出食管上皮异型增生91例,占9.50%。其中,轻度、中度和重度异型增生的检出率分别为7.72%、1.57%及0.21%。与1980年普查结果比较,癌和异型增生的检出率无明显差异(P>0.05)。结论林州市城郊乡普查人群中,食管癌和癌前病变的检出率未见降低。

Objective To investigate whether the prevalence rate of caneer and precursor lesions of esophagus is deelined in high-risk populations in Lingzhou,China.Methods A random sample matched in each sex ,age group and diserlbution of natural villages oas drawn from the Cheng Jiao commune of Linzhou where the endoscopic survey was performed in 527 high-risk populations for esophageal cancer in 1980.Nine hundred and fifty eight subjects were underwent to fiberoptic endosopic examination,complete with biopsy smpling in every case.Results Out of the 958 subgects,32cases（3.34%）were diagnosed as carinoma of the exophagus or the gastrie eardia ineluding 24 early and 8 advanced cancers ,Epithelial dysplasia of the esophagus was found in 91cases（9.5%）,and the detection rate of mild,moderate and severe type was in 7.72%,1.57%and 0.21%,respectively,No differences were observed in the prevalence rate of cancer and dysplasia in the two groups cercend in 1980 and 2004.Conclusion It might be suggested that the prevalence sophageal euremena and precaneerous lesions in the Cheng Jao commume of Linzhou is not declined from 1980 to 2004.