32例妊高征并发肝损害的临床特点及相关因素分析

Clinical feature and related risk factor in 32 cases of PIH with liver dysfunction

目的探讨妊娠高血压综合征(妊高征)并发肝损害病例的临床特点,症状、高血压的程度等因素与肝损害的相关性。方法对我院32例妊高征合并肝损害病例进行回顾性分析;根据患者的症状、水肿等的严重程度进行评分并与对照组(无肝损害的妊高症患者)比较。结果502例妊高征并发肝损害32例,肝损害多表现为血清转氨酶的轻、中度升高;与对照组比较,并发肝损害组ALB水平显著降低,凝血指标、肾功能两组间并无显著性差异;并发肝损害组的症状、高血压的程度的评分高于对照组,差异具有显著性(P<0.05);而水肿、24 h尿蛋白定量的评分两组间无显著性差异。结论妊高征并发肝损害多表现为轻、中度肝功能异常;肝损害多见于临床症状较重、血压明显升高的病例较多。

Objective To summarize the clinical feature of pregnancy-induced hypertension（PIH） with liver dysfunction and to investigate the associated risk factor related with liver dysfunction. Methods Thirty-two cases of PIH with hepatic insufficiency were analyzed retrospectively Score was recorder according to the degree of symptom, edema, hypertension and proteinuria. Results Among 502 cases of PIH, 32 cases were found liver dysfunction. ①Mild or moderate increasing serum transaminase was the most often clinical manifestation. ② The level of albumin in group of liver dysfunction was lower compare with the control＇ s（50 PIH without liver dysfunction）. There were no significant difference in index of renal tests and coagulation in the two liver dysfunction was higher than the control＇ s（P 〈 0.05 ） group , but s. ③ The score of symptom and hypertension in group of the score of edema and protein uria was no significant difference in the two groups. Conclusion Mild or moderate abnormality of liver function test was the most often clinical feature in cases of PIH with liver dysfunction. Hepatic insufficiency was easily been found in cases with severe clinical symptom and unmanageable hypertension.