急性冠脉综合征患者血清IL-18水平测定

Determination of serum IL-18 level in patients with acute coronary syndrome

目的检测急性冠脉综合征(ACS)患者血清白细胞介素18(IL-18)水平,并探讨其与ACS的关系。方法采用酶联免疫吸附法测定31例ACS患者(包括12例急性心肌梗死患者(AMI组)、19例不稳定型心绞痛患者(UAP组))和15例稳定型心绞痛患者(SAP组)及16例非冠心病患者(对照组)血清IL-18水平。结果AMI组和UAP组血清IL-18水平明显高于SAP组和对照组(P<0.01),SAP组血清IL-18水平明显高于对照组(P<0.01)。结论血清IL-18水平可反映动脉粥样硬化斑块的稳定性,可作为预测ACS发生的血清标志物。

Aim ： To measure the levels of interleukin-18 （IL-18） in the serum of patients with acute coronary syndrome （ACS） and explore its relation with ACS. Methods ：The serum concentrations of IL-18 were measured in 31 patients with ACS including 12 patients with acute myocardial infarction （AMI group） and 19 patients with unstable angina pectoris （UAP group）by enzyme-linked immunosorbent assay （ELISA）. Fifteen patients with stable angina pectoris （SAP group） and 16 controls without coronary diseases were used as control. Results： Serum IL-18 levels in AMI and UAP groups were significantly higher than those in SAP and control group （ P 〈 0..01 ）. Serum IL-18 levels in SAP group were significantly higher than those in control group（P 〈0,01 ）. Conclusion： Level of serum IL-18 can reflect the stable status of coronary atheroselerosis plaque. IL-18 can be a serum marker to predict the occurrence of ACS.