奥美拉唑、左氧氟沙星与阿莫西林三联疗法治疗幽门螺杆菌感染疗效观察

Effect of trilogy treatment of omeprazole, levofloxacin, and amoxicllin of helicobacter pylori infection

目的探讨奥美拉唑加左氧氟沙星、阿莫西林三联一周疗法根除幽门螺杆菌（Hp）的疗效及安全性。方法选择120例符合条件的阳性慢性胃炎和消化性溃疡患者随机分为2组,治疗组采用奥美拉唑（20mg,2次/d）、左氧氟沙星（200mg,2次/d）加阿莫西林（1000mg,2次/d）,治疗7d;溃疡患者继用奥美拉唑20mg,1次/d,3周;对照组采用奥美拉唑（20mg,2次/d）加阿莫西林（1000mg,2次/d）,治疗7d;溃疡患者维持治疗同上;疗程结束4周后复查,观察根除率、症状缓解率、溃疡愈合率及不良反应等。结果治疗组和对照组的症状缓解率、根除率、溃疡治愈率、不良反应发生率分别为94.7%、87.7%、12.3%和91.1%、82.1%、14.3%,2组差异无统计学意义（P〉005）。治疗组与对照组每例根除费用分别为256.05元、300.82元,治疗组根除期望成本比对照组低59.99元。结论奥美拉唑加左氧氟沙星加阿莫西林三联一周疗法是根除Hp的理想方案。

Objective To explore the therapeutic effect and safety of one-week trillogy treatment of omeprazole,levofloxacin, and amoxicillin on helicobacter pylori infection （ Hp ）. Methods 120 cases of plsitive chronic gastritis and peptic ulcer were randomly divided into two groups. The treatment group were treated with one-week trilogy of omeprazole（20 mg,twice a day） ,levofloxacin（200 mg,twice a day） ,and amoxicillin（ 100 mg,twice a day）, ulcer patients were treated only with omeprazole （ 20 g, once a day ） for 3 weeks while the control group were treated with omeprazole （20 mg tweice a day ）and amoxicllin （100 mg, twice a day ）for a week and the ulcer patients maintained the above treatment. 4 week treatment later the patients were rechecked. The eradication rate, remission rate and healing rate as well as adverse effect were observed. Results The remission rate, eradication rate, healing rate and incidence of adverese effect were 94.7% vs. 91.1% ,87.74% vs. 82.1% and 12.3% vs. 14.3% in treatment group and control group （ P 〉 0.05 ）. the cost for eradication was 256.05 yuan and 300.82 yuan in treatment group and control group. The expected xost of treatment group was 59.99 yuan lower than that of control group. Conclusion The one-week trilogy treatment of omeprazole,levofloxain, and amoxicillin is ideal protocol for the treatment of helicobacter pyloriinfection.