心力衰竭患者内皮素和降钙素基因相关肽的变化及其与心功能的关系

The Change of Endothelin and Calcitonin Gene Related Peptide and its Relationship with Cardiac Function in Patients with CHF

目的探讨充血性心力衰竭(CHF)患者血浆内皮素(ET)、降钙素基因相关肽CGRP的变化及其与心功能的关系。方法对入选的121例CHF患者测定了血浆ET和CGRP水平,超声心动图测量左室射血分数(LVEF),评价心功能,同时选择27例正常人作为对照组。结果CHF患者CGRP水平低于正常对照组,而血浆ET水平高于对照组(P<0.01);随着心功能恶化,CGRP水平逐渐降低,而血浆ET水平逐渐升高;相关分析表明;CHF患者血浆ET与CGRP水平和LVEF呈负相关,而血浆CGRP与LVEF呈正相关(P<0.01)。结论CHF患者血浆ET和CGRP参与了CHF的发生发展,其水平高低可反映CHF心功能损害程度。

Objective： To study the changes of endothelin （ET）, calcitonin gene related peptide （CGRP） and the effect of them on cardiac function in patients with congestive heart failure （CHF）. Methods： The plasma levels of ET and CGRP in 121 CHF patients were measured. Left ventricular ejection fraction （I.VEF） was from echocardiography. Results： The plasma levels of CGRP in patients with CHF were lower than that in control subjects. The plasma level of ET was higher than that in control subjects. The signifi- eant decreased in CGRP was correlated with increase of NYHA; and the levels of ET was on the eontrary. There were positive correlation between LVEF and the levels of CGRP （P〈0. 01）, and a negative correlation between I.VEF and the levels of ET. Conclusions.Imbalance of the levels of ET and CGRP play roles in pathophysiologieal and pathogenetie mechanism in CHF, and correlated with the severity of cardiac function.